• 05:00 DSM

  12:05 CHS
  6Hrs, 05m 1 Stop (DFW)
• DSMDes Moines Airport 05:00 - CHS 12:05 6h 05m 1 Stop (DFW) Dallas
• DSMDes Moines Airport 05:00
  DFWDallas/Fort Worth Intl Airport 08:27
• DFWDallas/Fort Worth Intl Airport 07:06
  CHSCharleston Airport 12:05
• 6h 05m (1h 21m)
• 1 Stop DFW · Dallas 1h 21m
• American Airlines (AA 2326)Airbus
  American Airlines (AA 1140)Airbus
• American Airlines (AA 2326)
• • M
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• 05:13 DSM

  12:05 CHS
  5Hrs, 52m 1 Stop (DFW)
• DSMDes Moines Airport 05:13 - CHS 12:05 5h 52m 1 Stop (DFW) Dallas
• DSMDes Moines Airport 05:13
  DFWDallas/Fort Worth Intl Airport 08:27
• DFWDallas/Fort Worth Intl Airport 07:19
  CHSCharleston Airport 12:05
• 5h 52m (1h 08m)
• 1 Stop DFW · Dallas 1h 08m
• American Airlines (AA 2326)Airbus
  American Airlines (AA 1140)Airbus
• American Airlines (AA 2326)
• • -
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• 05:15 DSM

  11:48 CHS
  5Hrs, 33m 1 Stop (DFW)
• DSMDes Moines Airport 05:15 - CHS 11:48 5h 33m 1 Stop (DFW) Dallas
• DSMDes Moines Airport 05:15
  DFWDallas/Fort Worth Intl Airport 08:08
• DFWDallas/Fort Worth Intl Airport 07:21
  CHSCharleston Airport 11:48
• 5h 33m (47m)
• 1 Stop DFW · Dallas 47m
• American Airlines (AA 2326)Airbus
  American Airlines (AA 3470)Embraer Emb 175
• American Airlines (AA 2326)
• • -
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• 05:32 DSM

  11:03 CHS
  4Hrs, 31m 1 Stop (ORD)
• DSMDes Moines Airport 05:32 - CHS 11:03 4h 31m 1 Stop (ORD) Chicago
• DSMDes Moines Airport 05:32
  ORDChicago O'Hare International Airport 07:45
• ORDChicago O'Hare International Airport 06:54
  CHSCharleston Airport 11:03
• 4h 31m (51m)
• 1 Stop ORD · Chicago 51m
• American Airlines (AA 2460)Airbus
  American Airlines (AA 2171)Airbus
• American Airlines (AA 2460)
• • -
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  • F
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  • S

• 05:32 DSM

  11:07 CHS
  4Hrs, 35m 1 Stop (ORD)
• DSMDes Moines Airport 05:32 - CHS 11:07 4h 35m 1 Stop (ORD) Chicago
• DSMDes Moines Airport 05:32
  ORDChicago O'Hare International Airport 07:45
• ORDChicago O'Hare International Airport 06:54
  CHSCharleston Airport 11:07
• 4h 35m (51m)
• 1 Stop ORD · Chicago 51m
• American Airlines (AA 2460)Airbus
  American Airlines (AA 3394)Embraer Emb 175
• American Airlines (AA 2460)
• • -
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• 05:32 DSM

  11:09 CHS
  4Hrs, 37m 1 Stop (ORD)
• DSMDes Moines Airport 05:32 - CHS 11:09 4h 37m 1 Stop (ORD) Chicago
• DSMDes Moines Airport 05:32
  ORDChicago O'Hare International Airport 07:51
• ORDChicago O'Hare International Airport 06:54
  CHSCharleston Airport 11:09
• 4h 37m (57m)
• 1 Stop ORD · Chicago 57m
• American Airlines (AA 2460)Airbus
  American Airlines (AA 3394)Embraer Emb 175
• American Airlines (AA 2460)
• • -
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• 10:10 BNA

  06:45 STL
  6Hrs, 00m 1 Stop (CHS)
• BNANashville Airport 10:10 - STL 06:45 6h 1 Stop (CHS) Charleston
• BNANashville Airport 10:10
  DSMDes Moines Airport 05:40
• CHSCharleston Airport 12:40
  STLSt Louis Lambert Intl Airport 06:45
• 6h (2h 10m)
• 1 Stop CHS · Charleston 2h 10m
• Southwest Airlines (WN 2576)Boeing 737 Max 8 Passenger
  Southwest Airlines (WN 1004)Boeing 737 700
• Southwest Airlines (WN 2576)
• • -
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• 06:00 DSM

  14:10 CHS
  7Hrs, 10m 1 Stop (STL)
• DSMDes Moines Airport 06:00 - CHS 14:10 7h 10m 1 Stop (STL) Saint Louis
• DSMDes Moines Airport 06:00
  STLSt Louis Lambert Intl Airport 11:10
• STLSt Louis Lambert Intl Airport 07:05
  CHSCharleston Airport 14:10
• 7h 10m (4h 05m)
• 1 Stop STL · Saint Louis 4h 05m
• Southwest Airlines (WN 1004)Boeing 737 Max 8 Passenger
  Southwest Airlines (WN 2454)Boeing 737 800
• Southwest Airlines (WN 1004)
• • M
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• 06:00 DSM

  14:50 CHS
  7Hrs, 50m 1 Stop (STL)
• DSMDes Moines Airport 06:00 - CHS 14:50 7h 50m 1 Stop (STL) Saint Louis
• DSMDes Moines Airport 06:00
  STLSt Louis Lambert Intl Airport 11:50
• STLSt Louis Lambert Intl Airport 07:05
  CHSCharleston Airport 14:50
• 7h 50m (4h 45m)
• 1 Stop STL · Saint Louis 4h 45m
• Southwest Airlines (WN 1004)Boeing 737 Max 8 Passenger
  Southwest Airlines (WN 2454)Boeing 737 800
• Southwest Airlines (WN 1004)
• • -
  • -
  • -
  • -
  • -
  • -
  • S

• 06:00 DSM

  12:00 CHS
  5Hrs, 00m 1 Stop (ORD)
• DSMDes Moines Airport 06:00 - CHS 12:00 5h 1 Stop (ORD) Chicago
• DSMDes Moines Airport 06:00
  ORDChicago O'Hare International Airport 08:40
• ORDChicago O'Hare International Airport 07:29
  CHSCharleston Airport 12:00
• 5h (1h 11m)
• 1 Stop ORD · Chicago 1h 11m
• American Airlines (AA 6416)Crj 700 Canadair Regional
  American Airlines (AA 3891)Embraer Emb 175
• American Airlines (AA 6416)
• • M
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• 06:45 DSM

  14:04 CHS
  6Hrs, 19m 1 Stop (DCA)
• DSMDes Moines Airport 06:45 - CHS 14:04 6h 19m 1 Stop (DCA) Washington
• DSMDes Moines Airport 06:45
  DCAWashington Ronald Reagan National Airport 12:26
• DCAWashington Ronald Reagan National Airport 10:16
  CHSCharleston Airport 14:04
• 6h 19m (2h 10m)
• 1 Stop DCA · Washington 2h 10m
• American Airlines (AA 5414)Crj 700 Canadair Regional
  American Airlines (AA 3075)Airbus
• American Airlines (AA 5414)
• • M
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• 06:45 DSM

  14:57 CHS
  7Hrs, 12m 1 Stop (CLT)
• DSMDes Moines Airport 06:45 - CHS 14:57 7h 12m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 06:45
  CLTCharlotte Airport 13:50
• CLTCharlotte Airport 10:05
  CHSCharleston Airport 14:57
• 7h 12m (3h 45m)
• 1 Stop CLT · Charlotte 3h 45m
• American Airlines (AA 2854)Airbus
  American Airlines (AA 5217)Canadair Regional
• American Airlines (AA 2854)
• • -
  • -
  • -
  • -
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  • S
  • -

• 06:45 DSM

  14:09 CHS
  6Hrs, 24m 1 Stop (DCA)
• DSMDes Moines Airport 06:45 - CHS 14:09 6h 24m 1 Stop (DCA) Washington
• DSMDes Moines Airport 06:45
  DCAWashington Ronald Reagan National Airport 12:27
• DCAWashington Ronald Reagan National Airport 10:16
  CHSCharleston Airport 14:09
• 6h 24m (2h 11m)
• 1 Stop DCA · Washington 2h 11m
• American Airlines (AA 5414)Crj 700 Canadair Regional
  American Airlines (AA 4450)Embraer Emb 175
• American Airlines (AA 5414)
• • -
  • -
  • -
  • -
  • -
  • S
  • -

• 06:45 DSM

  14:20 CHS
  6Hrs, 35m 1 Stop (CLT)
• DSMDes Moines Airport 06:45 - CHS 14:20 6h 35m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 06:45
  CLTCharlotte Airport 13:10
• CLTCharlotte Airport 10:07
  CHSCharleston Airport 14:20
• 6h 35m (3h 03m)
• 1 Stop CLT · Charlotte 3h 03m
• American Airlines (AA 2854)Airbus
  American Airlines (AA 958)Boeing 737 800
• American Airlines (AA 2854)
• • -
  • -
  • -
  • -
  • F
  • -
  • -

• 06:45 DSM

  14:20 CHS
  6Hrs, 35m 1 Stop (CLT)
• DSMDes Moines Airport 06:45 - CHS 14:20 6h 35m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 06:45
  CLTCharlotte Airport 13:10
• CLTCharlotte Airport 10:05
  CHSCharleston Airport 14:20
• 6h 35m (3h 05m)
• 1 Stop CLT · Charlotte 3h 05m
• American Airlines (AA 2854)Airbus
  American Airlines (AA 958)Boeing 737 800
• American Airlines (AA 2854)
• • M
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• 06:45 DSM

  15:35 CHS
  7Hrs, 50m 1 Stop (CLT)
• DSMDes Moines Airport 06:45 - CHS 15:35 7h 50m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 06:45
  CLTCharlotte Airport 14:30
• CLTCharlotte Airport 10:05
  CHSCharleston Airport 15:35
• 7h 50m (4h 25m)
• 1 Stop CLT · Charlotte 4h 25m
• American Airlines (AA 2854)Airbus
  American Airlines (AA 1643)Airbus
• American Airlines (AA 2854)
• • -
  • -
  • -
  • -
  • -
  • -
  • S

• 06:45 DSM

  15:28 CHS
  7Hrs, 43m 1 Stop (DCA)
• DSMDes Moines Airport 06:45 - CHS 15:28 7h 43m 1 Stop (DCA) Washington
• DSMDes Moines Airport 06:45
  DCAWashington Ronald Reagan National Airport 13:45
• DCAWashington Ronald Reagan National Airport 10:16
  CHSCharleston Airport 15:28
• 7h 43m (3h 29m)
• 1 Stop DCA · Washington 3h 29m
• American Airlines (AA 5414)Crj 700 Canadair Regional
  American Airlines (AA 4544)Embraer Emb 175
• American Airlines (AA 5414)
• • M
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• 06:45 DSM

  15:30 CHS
  7Hrs, 45m 1 Stop (CLT)
• DSMDes Moines Airport 06:45 - CHS 15:30 7h 45m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 06:45
  CLTCharlotte Airport 14:26
• CLTCharlotte Airport 10:05
  CHSCharleston Airport 15:30
• 7h 45m (4h 21m)
• 1 Stop CLT · Charlotte 4h 21m
• American Airlines (AA 2854)Airbus
  American Airlines (AA 1643)Airbus
• American Airlines (AA 2854)
• • M
  • T
  • W
  • T
  • -
  • -
  • -

• 06:45 DSM

  15:30 CHS
  7Hrs, 45m 1 Stop (CLT)
• DSMDes Moines Airport 06:45 - CHS 15:30 7h 45m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 06:45
  CLTCharlotte Airport 14:26
• CLTCharlotte Airport 10:07
  CHSCharleston Airport 15:30
• 7h 45m (4h 19m)
• 1 Stop CLT · Charlotte 4h 19m
• American Airlines (AA 2854)Airbus
  American Airlines (AA 1643)Airbus
• American Airlines (AA 2854)
• • -
  • -
  • -
  • -
  • F
  • -
  • -

• 06:45 DSM

  12:46 CHS
  5Hrs, 01m 1 Stop (CLT)
• DSMDes Moines Airport 06:45 - CHS 12:46 5h 01m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 06:45
  CLTCharlotte Airport 11:30
• CLTCharlotte Airport 10:05
  CHSCharleston Airport 12:46
• 5h 01m (1h 25m)
• 1 Stop CLT · Charlotte 1h 25m
• American Airlines (AA 2854)Airbus
  American Airlines (AA 1643)Airbus
• American Airlines (AA 2854)
• • -
  • -
  • -
  • -
  • -
  • S
  • -

• 07:00 DSM

  15:25 CHS
  7Hrs, 25m 1 Stop (DEN)
• DSMDes Moines Airport 07:00 - CHS 15:25 7h 25m 1 Stop (DEN) Denver
• DSMDes Moines Airport 07:00
  DENDenver Intl Airport 10:05
• DENDenver Intl Airport 07:55
  CHSCharleston Airport 15:25
• 7h 25m (2h 10m)
• 1 Stop DEN · Denver 2h 10m
• Southwest Airlines (WN 1457)Boeing 737 700
  Southwest Airlines (WN 2298)Boeing 737 700
• Southwest Airlines (WN 1457)
• • M
  • -
  • -
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  • F
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• 08:00 DSM

  16:25 CHS
  7Hrs, 25m 1 Stop (IAH)
• DSMDes Moines Airport 08:00 - CHS 16:25 7h 25m 1 Stop (IAH) Houston
• DSMDes Moines Airport 08:00
  IAHHouston George Bush Intercontinental Airport 12:53
• IAHHouston George Bush Intercontinental Airport 10:35
  CHSCharleston Airport 16:25
• 7h 25m (2h 18m)
• 1 Stop IAH · Houston 2h 18m
• United Airlines (UA 1982)Boeing 737 700
  United Airlines (UA 6049)Embraer 175
• United Airlines (UA 1982)
• • M
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  • T
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• 08:00 DSM

  16:25 CHS
  7Hrs, 25m 1 Stop (IAH)
• DSMDes Moines Airport 08:00 - CHS 16:25 7h 25m 1 Stop (IAH) Houston
• DSMDes Moines Airport 08:00
  IAHHouston George Bush Intercontinental Airport 12:53
• IAHHouston George Bush Intercontinental Airport 10:35
  CHSCharleston Airport 16:25
• 7h 25m (2h 18m)
• 1 Stop IAH · Houston 2h 18m
• United Airlines (UA 1982)Airbus
  United Airlines (UA 6049)Embraer 175
• United Airlines (UA 1982)
• • -
  • -
  • -
  • -
  • -
  • S
  • -

• 08:07 DSM

  13:59 CHS
  4Hrs, 52m 1 Stop (ORD)
• DSMDes Moines Airport 08:07 - CHS 13:59 4h 52m 1 Stop (ORD) Chicago
• DSMDes Moines Airport 08:07
  ORDChicago O'Hare International Airport 10:35
• ORDChicago O'Hare International Airport 09:38
  CHSCharleston Airport 13:59
• 4h 52m (57m)
• 1 Stop ORD · Chicago 57m
• United Airlines (UA 1363)Airbus
  United Airlines (UA 3493)Embraer 170
• United Airlines (UA 1363)
• • -
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• 08:07 DSM

  13:59 CHS
  4Hrs, 52m 1 Stop (ORD)
• DSMDes Moines Airport 08:07 - CHS 13:59 4h 52m 1 Stop (ORD) Chicago
• DSMDes Moines Airport 08:07
  ORDChicago O'Hare International Airport 10:35
• ORDChicago O'Hare International Airport 09:38
  CHSCharleston Airport 13:59
• 4h 52m (57m)
• 1 Stop ORD · Chicago 57m
• United Airlines (UA 1363)Airbus
  United Airlines (UA 3493)Embraer 170
• United Airlines (UA 1363)
• • M
  • -
  • -
  • -
  • -
  • -
  • S

• 08:30 DSM

  16:30 CHS
  7Hrs, 00m 1 Stop (STL)
• DSMDes Moines Airport 08:30 - CHS 16:30 7h 1 Stop (STL) Saint Louis
• DSMDes Moines Airport 08:30
  STLSt Louis Lambert Intl Airport 13:30
• STLSt Louis Lambert Intl Airport 09:35
  CHSCharleston Airport 16:30
• 7h (3h 55m)
• 1 Stop STL · Saint Louis 3h 55m
• Southwest Airlines (WN 1004)Boeing 737 700
  Southwest Airlines (WN 2454)Boeing 737 Max 8 Passenger
• Southwest Airlines (WN 1004)
• • -
  • -
  • -
  • -
  • -
  • S
  • -

• 12:48 DSM

  18:47 CHS
  4Hrs, 59m 1 Stop (DCA)
• DSMDes Moines Airport 12:48 - CHS 18:47 4h 59m 1 Stop (DCA) Washington
• DSMDes Moines Airport 12:48
  DCAWashington Ronald Reagan National Airport 16:59
• DCAWashington Ronald Reagan National Airport 16:19
  CHSCharleston Airport 18:47
• 4h 59m (40m)
• 1 Stop DCA · Washington 40m
• American Airlines (AA 5388)Crj 700 Canadair Regional
  American Airlines (AA 5056)Crj 700 Canadair Regional
• American Airlines (AA 5388)
• • -
  • T
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  • F
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  • S

• 12:48 DSM

  18:47 CHS
  4Hrs, 59m 1 Stop (DCA)
• DSMDes Moines Airport 12:48 - CHS 18:47 4h 59m 1 Stop (DCA) Washington
• DSMDes Moines Airport 12:48
  DCAWashington Ronald Reagan National Airport 16:59
• DCAWashington Ronald Reagan National Airport 16:19
  CHSCharleston Airport 18:47
• 4h 59m (40m)
• 1 Stop DCA · Washington 40m
• American Airlines (AA 5388)Crj 700 Canadair Regional
  American Airlines (AA 5097)Crj 700 Canadair Regional
• American Airlines (AA 5388)
• • M
  • -
  • -
  • -
  • -
  • -
  • -

• 14:01 DSM

  19:58 CHS
  4Hrs, 57m 1 Stop (CLT)
• DSMDes Moines Airport 14:01 - CHS 19:58 4h 57m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 14:01
  CLTCharlotte Airport 18:54
• CLTCharlotte Airport 17:23
  CHSCharleston Airport 19:58
• 4h 57m (1h 31m)
• 1 Stop CLT · Charlotte 1h 31m
• American Airlines (AA 2962)Airbus
  American Airlines (AA 1586)Airbus
• American Airlines (AA 2962)
• • M
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  • S

• 14:01 DSM

  22:04 CHS
  7Hrs, 03m 1 Stop (CLT)
• DSMDes Moines Airport 14:01 - CHS 22:04 7h 03m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 14:01
  CLTCharlotte Airport 20:56
• CLTCharlotte Airport 17:23
  CHSCharleston Airport 22:04
• 7h 03m (3h 33m)
• 1 Stop CLT · Charlotte 3h 33m
• American Airlines (AA 2962)Airbus
  American Airlines (AA 3064)Airbus
• American Airlines (AA 2962)
• • M
  • T
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  • T
  • F
  • S
  • S

• 15:34 DSM

  21:59 CHS
  5Hrs, 25m 1 Stop (ORD)
• DSMDes Moines Airport 15:34 - CHS 21:59 5h 25m 1 Stop (ORD) Chicago
• DSMDes Moines Airport 15:34
  ORDChicago O'Hare International Airport 18:35
• ORDChicago O'Hare International Airport 17:05
  CHSCharleston Airport 21:59
• 5h 25m (1h 30m)
• 1 Stop ORD · Chicago 1h 30m
• United Airlines (UA 1568)Boeing 737 700
  United Airlines (UA 617)Boeing 737 700
• United Airlines (UA 1568)
• • M
  • T
  • W
  • T
  • F
  • -
  • -

• 15:34 DSM

  21:59 CHS
  5Hrs, 25m 1 Stop (ORD)
• DSMDes Moines Airport 15:34 - CHS 21:59 5h 25m 1 Stop (ORD) Chicago
• DSMDes Moines Airport 15:34
  ORDChicago O'Hare International Airport 18:35
• ORDChicago O'Hare International Airport 17:08
  CHSCharleston Airport 21:59
• 5h 25m (1h 27m)
• 1 Stop ORD · Chicago 1h 27m
• United Airlines (UA 3533)Embraer 175
  United Airlines (UA 617)Boeing 737 900
• United Airlines (UA 3533)
• • -
  • -
  • -
  • -
  • -
  • -
  • S

• 15:34 DSM

  21:59 CHS
  5Hrs, 25m 1 Stop (ORD)
• DSMDes Moines Airport 15:34 - CHS 21:59 5h 25m 1 Stop (ORD) Chicago
• DSMDes Moines Airport 15:34
  ORDChicago O'Hare International Airport 18:35
• ORDChicago O'Hare International Airport 17:08
  CHSCharleston Airport 21:59
• 5h 25m (1h 27m)
• 1 Stop ORD · Chicago 1h 27m
• United Airlines (UA 3533)Embraer 175
  United Airlines (UA 617)Boeing 737 700
• United Airlines (UA 3533)
• • -
  • -
  • -
  • -
  • -
  • S
  • -